I've played in a handful of sessions of the Dresden Files RPG, and that's using the FUDGE/FATE system.
It's a great system for story-based gaming. Combat proved to be a bit clunky, but I chalk that more up to inexperience with the system than I do to a fault with the rules. Combat is supposed be more narrative than tactical in my opinion, and several of the players in my group are fans of D&D 4e for obvious reasons.
The method of character generation was awesome for creating a party of PCs who had reasons to band together. We ended up with my paranoid supernatural researcher dating a wizard-in-hiding who used the White Court vampire as an information source who was serving as a guardian angel of sorts for the private investigator who was checking out a suspicious magic dabbler/college professor who had previously taught a class attended by my supernatural researcher.
We all knew each other through someone else. It just worked, didn't feel forced, and made us want to help each other for reasons other than "they're in the party."