Moving away from D&D, The Great Pendragon Campaign surely counts. It covers the full story of King Arthur, from Britain under King Uther in 485 through the destruction of the Round Table and the death of Arthur at Camlann in 565, with a bit of a wrap-up to cover the Saxon conquest in later years. RuneQuest has Six Seasons in Sartar, which covers the exploits of some young adventurers over the course of six seasons in the city of Sartar (really, the name gives it away). Eyes of the Stone Thief is a big campaign for 13th Age that focuses on the titular living dungeon, the Stone Thief, as it hunts the PCs. Finally, for Symbaroum you've got the Throne of Thorns campaign, which covers six books, beginning with The Throne of Thorns and ending with Davokar Awakens. I think this is getting/already has a 5e adaptation.