Non-D&D: I'm gotten a ton of use from Spycraft, MnM, Call of Cthulhu, Polyherdon's mini-games, and Spaceship Zero. I've gotten some use out of Star Wars and d20 Modern.
D&D-wise, I've worn my psionics handbook to bits. I get a lot of use out of Mindscapes and Relics & Rituals 1 as well. Surprisingly, I'm using Monte's Requiem for a God book more than I am the Books of Eldrich Might. I use the Manual of the Planes a fair amount, as well. Even the Book of Vile Darkness has provided me with quite a bit of material.