Well, the new GHotR has gods killing gods, including Mystra, which unleashes the spellplague, unleashing all kinds of havoc. This is probably just on scale with the "Time of Troubles" from the 1e/2e conversion. However, there's a preview chapter of Salvatore's new book. This chapter is a "flash-forward" to 1485 or so, in which Drizz't reveals that the Shades

p) have reformed Netheril, most of civilization has collapsed outside of the Silver Marches area, the benevolent gods are in hiding or something, "two worlds have merged," there was a "coming of the aboleths," etc. All in all, it sounds like they points-of-lighted it quite heavily, though it's unsure exactly where it's going.