This series -Dorohedoro- which I'm currently watching on Netflix...
...It's the most bizarre anime I've watched in some time. It's Urban Fantasy, but it's got a strong punk vibe to it to the point that I feel it's some sort of Magic-punk subgenre.
The main protagonists are a man named Caiman who has a reptile's head (you eventually learn why) and a strange Sorcerer hiding within his body. I'm not far into the series, but he's continually captured enemy Sorcerers and stuffed them in his mouth so that the Sorcerer within can inspect and confirm whether they're the one he's looking for - very, very weird!
The other is a woman named Nikaido who dresses in turquoise coveralls, is a martial arts wiz and owns a hole-in-the-wall called The Bug. She specializes in gyozas, which Caiman is happy to eat all she can cook and never pay his tab, to the point that she's teetering on bankruptcy. But strangely, she seems very cool with all of that - say what !?
The antagonists are Sorcerers who work for a boss Sorcerer named En, who's deep into the culinary shroom biz. He seems happiest when he's reclining on one of his giant shrooms and puffing on jars of who knows what...
For some reason the Sorcerers in En's employ must always wear masks. There's apparently a right way and a wrong way to wear a mask and the antagonists are very conscious of it. Otherwise when they take them off, they're perfectly normal looking folk...um...except for the person in purple in this pic, who after removing their max proves to be a rather, fit and chesty Amazon of a women.
The story is set in a poor and crowded district within a city simply known as "The Hole", which sort of has a look like one of those Brazilian favela's. This is a picture of one of The Hole's nicer hoods.
I can envision running it with a number of the TTRPGs I own. But I'd need to have the right group of players, because every aspect of the setting is weird, if not down right bizarre.