Mearls has run 5E-powered Star Frontiers and Gamma World games at cons, meaning there has been some thought put into the idea: I think we may see it eventually, if the Edition is going strong and they have plumbed the depths of the main D&D settings.Gamma World- awesome, and unlikely. But possible! I'd love to see it.
But .... Star Frontiers? Could we hope? Puh-leeze?