I just ran an all-nighter last Friday that turned out quite good. We started a Genetech campaign, using some of the stuff from an old Dungeon magazine (don't remember which issue off the top of my head), and the campaign started with the PCs having to break out of a government installation where they were being held.
The PCs were being kept in individual cells, guarded heavily, and in an enclosed compound about five sq. miles. A few cool moments came up, including a Matrix-style lobby scene and a car chase in Hummers.
One of the PCs tried to get out of their cell by feigning illness, but failed to convince the on-cal doctor that was called to look at him, so the players had iterally seconds to devise a different plan. They al deciding to simultaneously start screaming their heads off, and - after I'd emphasised hoe little time they had - three grown men acrss the table from me starting shouting out obscenities and curses. It was a hilarious moment.
Following a lot of lock picking and unarmed fighting with nearby guards, the PCs got clear of their cells (leaving a single conscious guard behind locked in one of their cells). They found a security room and managed to find some weapons and a belt of flash-bang grenades, just in time to see a group of guards, armed with P90s, emerging from the lift across the hall from them. Getting mowed down by autofire, one PC (reduced to 1 HP) managed to throw a flash-bang, and stun some of the guards, right before passing out, iving the other PCs just enough time to take the guards out.
Following this, they decided to take the stairs up out of the basement area they were in, deciding that the body-strewn lift might not be such a good idea. They got to the top of the stairs, and peering around a corner into the main lobby area of the building, saw another patrol of guards heading for the lift, in order to help out the first patrol (now dead). The lift doors opened, betraying the PCs actions, and sending the patrol running towards the stairs. Large amounts of autofire, and subsequent reloading, and of course some martial arts later, and the most awesome lobby scene since the Matrix reloaded was over.
Finally the PCs made in out of the building and over the first perimeter fence in the compound, and out into the wood that covered an entire half of the compound. After some scuffles with patrols of guards, the PCs, who'd decided to follow the main road out of the compound, reached a car pool area / garage. One eager PC decides to make a rushed listen check at the garage door, before opening it, revealing several guards waiting to ambush the party. After dispatching the guards, the PCs discovered a military Hummer, complete with roof-mounted machine gun, and got it started just in time to see another Hummer (identical to theirs), come into view and block the road. The driver made an awesome drive check, and their vehicle managed to make it up onto the verge on the side of the road, narrowly missing a tree on one side, and the other Hummer on the other.
Breaking through a final security barrier at high speed, the two vehicles engaged in a high speed chase along a main road, dodging other vehicles, and both with gunners trying to take out each other's vehicles. After a lucky machine gun shot took out the opposing driver, his vehicle span off the road, and was left upturned in a ditch, leaving our heroes to get away towards the nearest city.
Possibly the best opening scene I've ever run. Awesome to run, and I guess the players enjoyed it, by the whoops of joy when they finally got away.