Well, speaking as an outside observer who has seen previews of the hero classes (based on relevant ability) in Dungeon/Polyedron, I can hope that they change the application of class/cross-class skills, or add to it, such as CoC use of profession templates (a list of relevant career skills as class skills).
And if Wizards going to include rules variants, I would love to see, in addition to HP and the standard VP/WP health system, a wound-level health system, such as those found in Vampire: The Masquerade or LUG's Star Trek RPG.