I take a break usually after running a full campaign, letting one of our other DMs take over for a campaign. This helps with the recharge, and I have months (at least) to get ready for the next campaign. Oddly with 5E I've not taken off for longer than a month between campaigns (which is probably why my 2nd campaign sucked), but with the end of my 3rd campaign GoSM I plan on taking a nice long break as another DM takes over.