In this respect, not that many games can rival CoC. Even Runequest requiers someone at the table to know the combat rules (though that need not be the GM).I ran Call of Cthulhu for three years before I ever opened a rule book. Hell, I still have never read the CoC rules other than skimming them. It's a testament to BRP's relative simplicity and elegance that I picked up everything I needed from having played the game first.
A more tactical game is different, though.

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.