However, if you're facing off against a wizard guarded by a few orcs, the better strategy would probably be to pick off the wizard with Deadly Strike first.
One thing I'm not measuring - time to defeat enemies.
In addition to the quoted suggestion, if you have one powerful enemy, who is dishing out effects that you cannot easily Parry, surrounded by others who are tough enough to take a normal weapon attack, then the number of rounds it takes to deal with those guards will be important. And Deadly Strike should be a good choice.
I don't think the monster abilities stack up well to this currently*, due to values for hit points and damage, PCs look like they can "ride out" such a scenario due to the very good results from Parry. Meaning that a constant Parry is likely better even in tactical situations that feel like the opposite could be true. This kind of "riding out" is exactly what is happening with Intoxicated. It takes the PCs typically twice as long to dispatch each enemy due to disadvantage on attacks. This obviously means the PCs are attacked twice as much (and with serious muscle from e.g. Bugbears and an Ogre) - however the amount of that damage that can be soaked more than offsets this effect.
One possible exception I can think of - a necromancer and his zombie cohort might do the trick (the more damage you can put into a zombie, the better chance it will stay down).
* I haven't demonstrated or modeled this at all, and am still a long way from doing so. It's just a general feeling.