Yes. I think this idea really even follows the spirit of the feature.
Even when a creature is making repeated saves against your magic, it is still resisting a spell you cast (again, your magic). Eldritch Stike undercut's that resistance, whether a new spell or one already in affect.
Also, this is a "high cost" combination really IMO. You have to be a minimum of 12th level to pull it off (Fighter 10/Paladin 2) as far as Wraithful Smite (or use a feat to gain access to the spell). Action Surge is limited as well. Other spells, such as Hold Person or Slow are higher level spells for an EK (Slow wouldn't even be accessable until 13th level EK).
Sure, it is potentially a powerful combination, but many of those exist in 5E.
I agree, and also this is on a fighter which is kind of underpowered at this level anyway at this level.
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