Here I was thinking it was more like putting mods on "ignore". You can do it, but may wind up being SOL if you don't see the moderator's request or command.
Edit: Can't speak for other posters, but I've always felt apprehensive about unsubscribe links in emails.
Semi related link... i think
E-mailers Flunk the Unsubscribe Test - ClickZ
It works - I tested it myself!