Neonchameleon
Legend
It depends how you do it, especially with NPCs. If you apply a "kill on sight" policy then in my experience players don't bother to form anything like as many or as deep bonds because they know that the DM will treat them as targets even in places where the narrative barely supports it. So you get increased focus in the moment at the cost of ending up with a bunch of murderhobos who deliberately do not form deep links with anything other than fellow PCs because the biggest thing it does is to give targets to the bad guys.It's not about encounter balance as I've already stated upthread. Putting pressure on resources like familiars, pets, hirelings, mounts, vehicles, NPCs they are supposed to protect for a quest, etc. generates in my experience more (good) tension than solely focusing on the PCs' hit points. Players will tend to - again, in my experience - really focus and strategize in these moments which increases player engagement and, when they manage to achieve victory, they really feel like they did something notable.
If you are moderate about things and occasionally target the NPCs and supports then you can get them to not think it's pointless. But this takes moderation and not having fanatical monsters who use a "kill on sight" approach. Ones who are in general more interested in taking down the wizard than the familiar.
Oh, I will take out familiars, companions, hirelings, and mounts with appropriate set-up. But this isn't at all the same as "Kill on sight" where you sacrifice believability of the setting to set up a tactical challenge.It has absolutely nothing to do with hating familiars or not knowing how to balance encounters, at least where I'm concerned. It's simply presenting them with an additional problem to solve. I heartily recommend trying it.