I too think Eberron is a standout. It obviously holds on to a lot of D&D'Souza tropes -- intentionally so -- but I think it remixes a lot of them in a really cool way. Especially for the time it came out, u think it is a great fantastical setting.
And while I don't particularly like the Cypher system, Numenera embraced a gonzo science fantasy post post apocalyptic far future in a way I don't think we had seen in a very long time. I don't know that the 9th World is a setting I car about, but it is a phenomenal milieu. And the art. Soooo good.