I too think Eberron is a standout. It obviously holds on to a lot of D&D'Souza tropes -- intentionally so -- but I think it remixes a lot of them in a really cool way. Especially for the time it came out, u think it is a great fantastical setting.
And while I don't particularly like the Cypher system, Numenera embraced a gonzo science fantasy post post apocalyptic far future in a way I don't think we had seen in a very long time. I don't know that the 9th World is a setting I car about, but it is a phenomenal milieu. And the art. Soooo good.
Bastion from Electric Bastionland is probably my favourite. Early 20thC technology level doesn't come up much in fantasy games.
(I'm not counting CoC style games that are actually set in that there real 20th century)