Rune
Once A Fool
For instance, ChattyDM took elements from Apocalypse One, Mouseguard and Burning Wheel to change the Skill Challenge mechanic to what I think is pretty dang cool. Here's an example of it in action.
Burning Wheel has a concept of failed checks, called "Let it Ride", in that to do A task, you only get one try. So no "I failed my search check, I search again". A failure stands. This would move away from continually making a check - screeching the play to a halt - when PCs need to succeed at a skill for things to move forward.
Which goes nicely with Mouseguard's idea of failure - when you fail at something, you succeed at what you're trying to do. But a new complication is added. For instance, failing to jump over a river doesn't mean you fall in the river - it does mean you drop your pack with the McGuffin in the river, and have to chase it down stream.
One other thing I really like about Mouseguard--and would like to see in D&D--is the ability and incentive for players to use their own PCs' traits and flaws against themselves.