I have used Pathbuilder on my PC with an emulator (Bluestacks) and it works great. I've used it to create NPCs, mostly fighters and sorcerers, but it works OK for anything I need for the current campaign. Just export to pdf and then email it to myself.
Since this thread started out with comments about the Gamemastery Guide, I should say I haven't had time to read it all yet, but it looks very cool indeed. Intelligent items are always very cool. The NPC profiles are highly useful, even if they bear little relationship with the NPCs you can develop following the PC-creation rules. Looks like the general feeling is that you create NPC like creating monsters, and give them one or two signature powers from the class they are most associated with, and call it a day.
I'm mildly disappointed with the level of abstraction chosen for the vehicle rules, as if one set of vehicle rules could cover everything from a chariot to a warship. But at least it gives a framework for 3pp to jump into the breach and provide more specific rules, say, for sailing ships, as I intend to do.
Our last PF2 game was a great time for all, except most of the players haven't yet grasped how they should spend their hero points, or how they should react when one of their own goes down to enemy fire. One PC died, mostly because the other PCs were too busy fighting the enemy to spare a Battle Medicine action, and the PC in question had already spent all his hero points on die rolls to heal other PCs. A sad day, to be sure, and a lack of teamwork. But them's the breaks, as they say.