Aaaaactually.......
If that frost giant is 15' tall, that axe in the picture is approx. 7-8ft long....agreed not easy. If however you take the view that a Greatsword is analogue to a traditional claymore, and a greataxe something like a danish/sparth axe, that puts length in the region of 5-5.5ft. A particularly strong individual (in D&D parlance, 20 STR puts someone stronger than an ogre), could in theory chop a foot or so off the haft and use the weapon two handed.
In theory.....
However, from the weight alone you'd want some kind of penalty I would say. If you were desperate to allow it. And if there was good reason in narrative terms.
[NB: I'm largely being contrary here. I'm just saying that verisimilitude in D&D is a really flexible thing and in a slightly crazy, Megasword style game, then having a houserule in the back pocket for crazy-size weapons isn't to worst thing in the world...]