My girlfriend tried it with us this weekend in her 4E game. We're currently midway through the new Tomb of Horrors super adventure. It was a much better solution that Skype or Oovoo since the multipoint videoconferencing is free, rather than having to pay past 2 with Skype or past 3 with Oovoo.
We haven't found a great virtual whiteboard/tabletop yet, and we've tried a few, but we're definitely going to keep using Google+ hangouts for our multipoint videoconferencing. It actually looks like I'm going to be running Zeitgeist the same way.