Nightchilde-2 said:The New (and highly superior IMHO..and I LOVED the original WoD) WoD was designed for the ground up to be much friendlier to crossovers.
Well, kind of. Setting down a common set of core rules will make them a bit friendlier mechanically - there won't be as much conversion to get a given effect to work in a different setting. But in balance terms, various posts on the WW boards suggest the authors have no real intention of shooting for balance between the different books, so you might find that some amount of conversion is still necessary if having a balanced power level is important to a particular crossover.
So far as the original thread topic goes, I think the fundamental question is: what style of game are you shooting for? GURPS is IMHO better at simulating a relatively realistic gameworld, while World of Darkness is better for a more cinematic sort of game. GURPS allows you to define your characters more finely, WoD will probably be a lot easier for players new to the system to create what they want to play. If you're playing a game with a lot of talking and only rolling dice in critical situations, WoD is probably better - it'll certainly play a lot faster. OTOH if you prefer a more tactical or "wargamey" feel, or if most situations are to be resolved with dice (for a skill roll or whatever else), GURPS is probably better.