Far more likely, IME, is that while the campaign might start in or near the hometown of at least one PC it very quickly moves away from there and probably (as in close-to-certainly) never returns.
My experience, both as player and DM, is that players will tend to have their PCs gravitate to either a) a shared home base made by one or all of them or b) the nearest big city they can find until they find a bigger one. Rarely a PC will try to go home, slightly more often a PC will bring its family along to the big city once said PC has made neough wealth to support them there.