Yes, or at least sort of. One of the guiding principles of Eberron was that everything that was in D&D had a home there, which would include Epic. In particular, the "Dragon island" of Argonessen was called out as the Epic playground.
But I don't recall if there were any Epic-level NPCs statted up. Certainly, it didn't have anyone on a par with Drizzt (not actually Epic BTW, at least in 3e) or Elminster.
Humanoid "good guy" NPCs I don't recall there being many. I think Jaela Daran as the Keeper of the Flame (when she has her Keeper powers) might be one of the highest, but it pretty much says she stays at Flamekeep and doesn't have nearly the same reach. Even the Lord of Blades (one of the major NPCs in the setting) is only I think around levels 14 or 15. Lady Vol is another, but she's really more an enemy than she is someone who would ever help a PC out.
Pretty much anything else that is high powered is really more "monster" than "NPC"-- the Lords of Dust, the Quori, the Daelkyr, the dragons etc.