I have never been afraid to have plot in my games (and yes I know that makes me a bad DM and no, I don't care) but no, the meta-plot of FR, DL, DS...not that interested. Except in thinking that it has been a problem for those settings. I am using Sigil right now, and it is, of course, pre-faction war (because otherwise whats the point?) but again what will be important is the stuff I make up, and the plot it implies (there I go again).
D&D core does not have meta-plot, but it does have default setting assumptions that change with each addition, and stories connected to not-campaign specific entities (say Graz'zt). This can also be pretty annoying. But I can just keep ignoring and pushing my own plot.