I think the irony is is that TSR would have thrived in the current rpg enviroment, with stuff like kickstarter campaigns, pdfs, ect... they could have tailored there production far more to thier consumers, the current era of rpg allows for more flexiblity, makes it easier to dodge products that will be unpopular, ect...
If TSR had had these options like Print on Demand, PDFs, Kickstarters, Surveys, forums, virtual tables, ect... they would never have gone under, they would still have been able to produce most or all the content that they did.
Most of the problems could have been avoided, costs would have been cut ect...
I like Mike Mearls, but he's shouldn't be comparing how 5th edition is being handled to how TSR handled things, or how pre hasbro WotC handled things or hasbro has handled things in 4e.
If Sword Coast Adventurer's Guide had been a kickstarter (or another companies equivilant), it would have been a huge success, why?
Stretch goals, more player feedback, it would have been more about what fans wanted in it, then what WotC wanted to put in it.
So if player's wanted more gods make it a stretch goal, if wanted more details on regions make it a stretch goal, more player content make it a stretch goal, more locations like Kara Tur, Zakahara, Osse, Abier, ect... make them stretch goals.
You don't have to worry about having a product running at a loss.