... break glass?
Well, I guess it depends on how wrapped up I was in the current game and how interested I was in running something else.
It would not be beyond me to make the players make new PCs and have someone hire or otherwise importune them to go and recover their former PCs remains/investigate something they were looking into/etc.
After all, many adventures have "such and such are missing and we need you to find out why" moments; this would be the perfect opportunity for such an event.