How incompatible do they need to be? Some people would claim that about Shadowrun 4e. Traveler the New Era certainly was. Each edition of Villains and Vigilantes has been pretty significantly different from the prior, and the 1st and 2nd were both from the same publisher. Gamma World had a notorious range of game system versions. Mekton changed to various degrees with each edition, and none of them were entirely intercompatible.
Not all of these have the same publishers, but at least some of them did.