D&D 5E List of instant death spells in 5e


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Maybe a Banshee's Wail?

Wail (1/Day). The banshee releases a mournful wail, provided
that she isn't in sunlight. This wail has no effect on constructs
and undead. All other creatures within 30 feet of her that can
hear her must make a DC 13 Constitution saving throw. On
a failure, a creature drops to 0 hit points. On a success, a
creature takes 10 (3d6) psychic damage.
 


Another possibility is an intellect devourer assassin. Unless an autopsy is done there is no outward evidence of a brain eaten from the inside.
 



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