My current 4e campaign has several artefacts in it:
* The Eye of Venca (which Vecna tried to get back, but didn't);
* The Sword of Kas (which the PCs recently recovered, after returning it to Kas 15 levels ago);
* Whelm, a dwarven thrower hammer reforged into the two-handed Maul Overwhelm;
* The Crystal of Ebon Flame, in which is trapped Ygorl, the Slaad Lord of Entropy;
* And the Rod of Seven Parts, currently with six collected.
* The Eye of Venca (which Vecna tried to get back, but didn't);
* The Sword of Kas (which the PCs recently recovered, after returning it to Kas 15 levels ago);
* Whelm, a dwarven thrower hammer reforged into the two-handed Maul Overwhelm;
* The Crystal of Ebon Flame, in which is trapped Ygorl, the Slaad Lord of Entropy;
* And the Rod of Seven Parts, currently with six collected.