I'm running a campaign world in which there is only one 'god.' Here's the part where I ramble on and on about how proud I am of my campaign setting. Ignore if you wish.
Aunathor is the One True God of the Kethian Empire. He is the only god that is legally venerated by the empire, although cults to other powers exist. It is important to note that none of these other powers are actual gods at all. The Archomentals, Demon Lords, Arch Devils, Celestial Champions, and the Slaad Lords are merely powerful outsiders. Other cults exist that revere concepts such as Nature and The Void, but most readily accept that there is no entity behind the worship (some would argue).
This god Aunathor is served by the Seven Champions (basically take the Archon Lords from the BoED and make them servitors and champions of different concepts).
Aunathor is a deity of Goodness, Justice, and often wacky portfolio of Law. Clerics who worship under Aunathor can be LG, NG, or LN and have access to the Creation, Glory, Good, Healing, Law, Nobility, Purification, Renewal, and Sun domains. Usually clerics follow one of the champions as well. This affords them access to special domains of the concepts that the champions represent.
Barachiel serves as a a champion of warriors who spread words of peace and goodwill to the downtrodden. Clerics can be LG, NG, LN and have access to the Herald, War domains.
Domiel serves as champion of those who actively seek out evil... and stop it, usually using more 'clandestine' methods. Clerics can be LG or NG and have access to the Celestial and Retribution domains.
Pistis Sophia is a champion of those who seek both physical and mental perfection, usually monks. Clerics can be LG or LN and have access to the Celerity and Celestial domains.
Erathaol serves as champion to seers and mystics, those who seek out knowledge to better the world. Clerics can be LG or NG and have access to the Oracle and Prophecy domains.
Raziel is the crusader, the warrior who takes evil by the throat and throttles it. Clerics can be LG, NG, or LN and have access to the War and Wrath domains.
Sealtiel is the protector of the innocent and those two weak to fend for themselves. Clerics can be LG or NG and have access to the Endurance and Protection domains.
Zaphkiel is the watcher. Those who follow Zaphkiel detach themselves from the world in order to better understand their god and the world around them. Clerics can be LG, NG, or LN and have access to the Celestial and Knowledge domains.
Now despite the fact that Aunathor is a 'good' deity, many things that have been done in his name have not been good. The Long Silence was endured when all Clerics of Aunathor were stripped of their divine powers during the bloody crusades against the jungle Empire of Pomara.
The followers of the Champions also agree on very little. Raziel and Barachiel's followers get along rather well (usually), but there exists enmity between them and others like Domiel, Zaphkiel, and Erathaol. This usually doesn't result in violence although there have been incidents in the past.
The next major problem results from the fact that no one knows whether Aunathor actually exists or not. Spells that attempt to contact him are mysteriously redirected to either one of his many Solars, or one of the Champions. His worshippers know that they get there spells from *somewhere,* but they don't know where exactly.
Now, let it not be known that Aunathor is the 'only' god in the world. The Jungle Empire of Pomara worships the Creator Serpent Zul, who is served by four Couatls, the Serpents of Time, Death, Life, and Chaos respectively. Zul itself is said to be a Couatl of titanic proportions, one who created the world and left it in the hands of his four children.
The Kethians claim that Zul is a heathen deity with a heathen religion and bring into doubt its actual existence. Knowledgeable scholars, however, claim that in some of the more ancient texts surrounding Aunathor, that he was once closely associated with the couatl, but now no longer is.