Hm... in the past.. we had some doozies...
But right now, I've got the oddest mix, but it's because odd mixes are what the group is all about.
Human Male Fast Hero (d20 modern Doctor)
Human Male German WWII Soldier (V for Victory)
Fox Hengeyokai Female Shaman (OA)
Half-Elf Female Druid (PHB)
Halfling Female Witch (Quintessential Witch)
My wife, sister, and friends all play, I'm the DM, and they leap from reality to reality, and must accomplish certain objectives, hoping that they'll eventually unlock the way home... (Exiles + Quantum Leap + Sliders)
We've been having a blast so far.. the biggest hurdle has been currency. The language barrier was taken care of by a Farscape DRD that lives in the demiplane (a desert with a Starbucks) along with a few other characters. At first, the language barrier was hilarious, since I made Common, English, and Basic (SW) all different languages, and because of the translator microbes let them understand what OTHERS say, it doesn't let them communicate back. Now they're 4th level, and have taken various langauges as skills.
Chris