Mistwell
Crusty Old Meatwad
Attacks are not checks, so Hex won't do this.
That said, there are a handful of things that involve making an athletics check (grapple for example as I recall) and there Hex is brutal with it's "1st level have disadvantage, no save". Also could be fun if you've got an assassin on your team who hides a lot and you give a disadvantage on Wis to the target. Good luck with that.
Halfling warlock hiding behind a human is going to rock it out there.
That makes sense. OK, so Hex is more of a non-combat thing, rather than a combat thing. The witch hexes you with a curse, so now a lot of stuff you normally do fine, you do poorly. Makes sense.