Well, it is somewhat quirky, but then again, I had a character who met a giant lady once too, which I'll get to in a minute. As long as nobody is going into graphic detail and it's all 'wink wink nudge nudge' I don't see it being a problem unless someone at the table specifically thinks it is.
As for my charcter, it was during the Return to the Tomb of Horrors, when you try to find Desato's mountain fortress and it's controlled by a family of mountain giants.
I asked the party if given the chance to parley, we should take it, instead of the usual kill and loot. So we managed to get the matron alone without other giants at one point. Fortunately I was "equipped" with a couple potions of growth or whatever they were called in 2E.
Though it had potential to be a dangerous "encounter", it was much less dangerous than pretty much everything past that.
