Most likely not, for one big reason.
When considering a site for sales, a publisher has to ask whether or not the site will bring them NEW customers, or simply cannibalize their sales from another source. If it's the latter, it's most often not worth it.
Signing with DTRPG or E23, for example, is often seen as worth it because both stores have regular customers that are not found elsewhere (White Wolf and Steve Jackson Games diehards, who don't frequent other locations). Even with that, however, RPGNow vendors I've spoken with report sales from those locations are often 1/10 to 1/4 of what they're seeing from RPGNow.
According to my company's own sales data, E.N. World members are responsible for roughly 20% of my sales (according to the source links). I'm not convinced that the new site will result in NEW customers, or simply just represent that same number of people, buying from a different location. At this point, it makes more sense for me to sit back for at least a quarter, and see if those customers still come to me, or if they're making the move to the new site.