Based on the Cubicle 7 product blurb and the current societal zeitgeist, I also can't help but wonder if the main premise will be that "citizen PCs" uncover the many totalitarian lies upon which the Imperium is founded, and then take action to subvert it. I think that would be pretty cool.
EDIT: The title of the game, i.e., "accursed/damned empire," also indicates up front that the Imperium of Man itself is far from a bastion of good. Conversely, the title "Dark Heresy" suggested that the evil was primarily external. The latter will of course remain the dominant in-game propaganda, but I wonder if Imperium Maledictum will place more emphasis on the former as the basis for campaigns going forward.
Then again, I'm sure the die hard GW adherents on these boards will chime in if current GW lore provides additional insights into the direction C7 might take with the RPG. My knowledge is superficial at best.