As an avid user of the character builder and the monster builder this change affects me . . . well, not at all.
The loss of iPlay4e affects me . . . not at all.
Personally, I don't see what the big deal is. The only thing this affects are the people who wanted to get the entire 4th Ed. "crunch" library for a one month DDI subscription. While this is unfortunate for them, I have a hard time arguing against the decision. The CB has already cut into sales of books at my FLGS (obviously every store is different). At my FLGS though the overwhelming sentiment is "Why would I buy the book for $30 when its already included in my DDI account?" The books that do sell well, not surprisingly, are the more DM oriented books like Plane Above/Below, DMG2, etc. I personally do not have a problem with WotC saying "If you want to continue to access our content, you have to pay for it."
That being said, I will confess that it may have been better to handle this as downloadable "expansions" for the CB -- of course then people would also complain about the added cost. My guess is that next edition may be largely, if not entirely, PDF/e-Book based.
I understand that people who use iPlay4e, etc. will be affected. Personally though, from my experience, taking cell phones, tablets, and laptops away from the table is a positive thing. Too often, the players who use these devices spend their time playing with said devices and not playing with the rest of the table.
The other thing to consider here too is that this might, finally, be the first step in getting a VTT going. Having everything web/subscription based makes it easier to develop/fix things I would think (though I am not a programmer).