I once played a beer and pretzels RPG that used 2d6. Character creation took less than a minute, because every time you did something, you rolled 2d6. If you EVER roll snake eyes, you die. The goal as a player is to die as many times as possible due to rolling snake eyes, while the DM wants you to die from the game (also fairly common). In theory you could just try to survive, but that's really not the fun of the game.
From what I remember, the basic mechanics are based on rolling 2d6 against a TN of 7. All modifiers use the word "very," so a "very hard" task is TN +1, while being "very good" at something is TN -1. The reverse is also true if you attempt a "very easy" task or are "very bad" at it. I don't remember much else about the game, because alcohol was involved.