Sure.
Hellsing. Hellsing. Hellsing. Get it?
Hellsing is really a very cool show. Sorta like a World of Darkness vampire game or something. Set in modern-day England, it's a very plot-filled story about a group known as the Royal Protestant Knight Orginisation Hellsing, led by Lady Integral Wingates Hellsing. They are a semi-governmental secret orginisation that is dedicated to destroying vampires. In order to do so, however, somewhere in the history of the group they aquired a vampire willing to fight for them. The Hellsing orginsation is also at a sort of "cold war" state with the Iscariote Institution, a secret branch of the Roman Catholic church that also hunts vampires, and has their own "ace in the hole", although that I will leave for you to discover. As well, someone has figured out a way to make "controled vampires" through some technological process, and the vampire problem is getting out of control. And come on... any group that has the motto/oath
"In the name of God, impure souls of the living dead shall be banished into eternal damnation. Amen." gets a gold star in my book.

I _think_ It's finished it's run in Japan, although I think only the first seven episodes have thus far been translated. If you have it, watch it now. If you don't have it, get it and watch it now
Magical Nyan-Nyan Taruto. Don't ask me WHY I watched this... I don't remember who gave it to me... but I did. I still have no clue what it's about, I think I missed something... But it's funny at times. Complete at 12 episodes, all of which are subbed.
Hana Yori Dango - It's not new, but a lot of people have never seen it. Now, what I'm going to say might turn some people away, but bear with me... It's a soap opera done right. Complete (long ago complete) at 52 episodes, all of which are subbed. You can download it (if you have the patience) from fumeianime.com. The movie isn't part of the same story arc, it's a retelling in a different setting.
One that's been out in America for a long time, but I'm one of the few people localy who has ever heard of it, is Roujin Z. It's a semi-serious anime... That is, it has a very serious message, but told with some humor. I couldn't begin to describe the plot, but I'll just mention... One of the key plot details is a sentient, top-secret, nuclear powered, military developed, transforming, self-mobile, over-protective hospital bed. Take that as you will.
Angel Sanctuary is another one that's been out for a little while in America but hasn't really caught on. For good reason I suppose. All that's out is a 3 ep OAV, which is just a little fraction of a 20 volume manga series. The manga is quite good (I have the first 10 volumes... It's only in japanese though, so be sure you have a way to get it translated

)... So is the OAV, what there is of it, but the biggest problem is there isn't enough. Still, it's a good watch... Unless you run away screaming at animated portrayals of incest, transvestites, and messed up portrayals of real-world religions. Then stay far away. Far, far, far away.