If your adventure relies on the characters being able to use the portal (i.e. if it's just a "plot device" portal to bring them to the dungeon or something), feel free to DMify it and make it a skill challenge. Applicable skills include arcana (obviously), dungineering (because of its relation to the far-realms), and history (you've heard tales of similar portals), and maybe thievery (to fiddle with the components of the portal)
If they succeed at the challenge, hooray, the portal opens. If not, they still open the portal, but perhaps not to the right place, or perhaps there is a magical mishap that damages them (take away a healing surge), or when they appear at their destination, some interdimensional baddies (foulspawn?) have "latched" on to them and appear at the same location.