I once played a ranger who traumatically lost his wife to a (possibly magical) wolf, and in the process was gravely wounded. Unable to deal with the loss, his shattered mind came up with the belief that he had been infected with lycanthropy by the wolf, and killed his wife himself as a werewolf. The entire campaign he was secretly searching for a 'cure' to his condition, but remove curse never seemed to do the trick, since he had an insanity, not a magical curse.
Every full moon, he'd ditch the party at night, strip off his equipment, and stalk the nearest humanoids and kill them bare handed, then come to his senses the next day, clean up, get his equipment, silently bemoan his affliction, and rejoin the group. Between his dissaperances and the monthly stories of peasants horribly murdered, the group eventually figured out that he was a werewolf. Boy were they surprized when they finally confronted him on the night of a full moon and he didn't transform, simply started frothing at the mouth and leap at one of them using his hands and teeth.
He also always refused silver items and coins in treasure, and displayed a pyschosomatic rash/burning sensation whenever silver touched him.
Eventually, after 11th level, he finally got cured with a heal spell, since that could cure insanity, but up until then, he was the driving force of the party to accept new quests from various churches and wizards in order to earn a cure.