Was going to run Pathfinder Rise of the Runelords, but not that sure now, especially now I have read #4 Fortress of the Stone Giants, and there may not be 4e stone giants in 1st MM?
Usually run a homebrew - one we have developed over many years, but like others, I am seeing the benefits of putting that energy into making great adventures, rather than worlds - as the players seem to appreciate that more. (As much as I LOVE creating settings).
So we may just have a few test run adventures using the 4E modules first....then I would love to create a new setting (but one not so strict on what is allowed...you know, like Mike Mearls said some time ago, 'If someone wants to play a Cleric of Thor - let them'. Start with the characters and then build around them - as others here have suggested).
C