One of the greatest tactical errors I see people make all the time is to roll all their attacks on the same foe at once when they might drop him in one blow or shot, and might want to switch to different targets with their remaining attacks.
Regardless of how you get multiple attacks, you never have to use all your attacks on the same target; any valid target for that given attack, is fine, and for the next attack you can hit a DIFFERENT target, if you want to.