Dungeon Crawl Inc first comics are made with sprites; it becomes progresively better (in art and humor) with time.
Also Heroes Of Lesser Earth (H.O.L.E.), the first D&D webcomic with a Warlock ("How many times per day you can do that?" "14400" "And you say you´re limited?")
A Gamer's Pair of Dice - a gaming webcomic network. Goblins just joined, that's where I saw it. I haven't had a chance to look at the rest, but the art looks fantastic on all of them.
I've collected a link list with a lot of webcomics over the years. You can find it here. Quite a few of them are gaming-related, but I'd have to look at most of them to remember which are which...
