For Completeness Sake
The bus that gets closest to Game Empire is the number 25. But, it can be a bit of a ride. The fastest way really is to take the number 20 downtown, then transfer to the 25 at the Clairemont Blvd stop. Ask the driver for details.
But, you do have to pay a higher fare for the 20, which is the one downside.
Now, it is a bit of a walk from the trolley to Game Towne. The 5 bus from downtown will get you closer -within a block- but it does take longer to get there.
However you get to where you want to go, you will pass through some interesting neighborhoods.