I liked several things about D&D 4e. However, when I look at it, the following always crosses my mind:
1. I don't like Paragon Paths and Epic Destinies so I know that I will never run or play those levels.
2. Things that I want are spread out across too many books and Dragon Magazine
3. Too many specific names on feats and powers (e.g. the deity named feats). Trying to rename feats and powers or changing power descriptions to fit my campaign setting is going to be a reference nightmare for my players.
4. When I look at the power system, I think to myself, "Hero System does powers better so why not just use Fantasy Hero 4e or 5e?" (which is why I laughed when [MENTION=6563]Azzy[/MENTION] told [MENTION=6801328]Elfcrusher[/MENTION] that he would not like Hero System).
However, to the OP, if it looks interesting to you, give it a try.