Wow! Quite the debate. I am probably not helping here, but I will pipe up from my perspective. Why? Because I have done so in the past, and I will do so in the future. I don't expect to influence any policy, but hey, I am a customer. So maybe some of you will find my perspective, singular though it may (or may not) be, to be useful.
I don't quite see the big deal here. First of all, this isn't the first time the idea has come up. Secondly, I honestly don't see most of the products anymore. I have higher bandwidth connections than I have in the past, but there isn't time for me to hunt and peck for stuff.
Search is useful, but it is only as good as your descriptions. There have been products out there that I remember seeing blurbs about, but cannot find on RPGNow using any keywords I can think of. So while there may be changes RPGNow can put in place to make it better to search, you also need to remember that you need to represent your products effectively.
There are too many products for me to go through so increasingly I am just sticking with the folks I know and recognize.
I hope small publishers can be successful, but when it is too much work for me to find you, I am not going to buy your stuff.
I can see concerns with losing the exposure to the 'big boys'. But I also see advantages to splitting the sales base and making it quicker and easier for me to find you. *shrug* So long as it isn't any more inconvenient to me than it already is, I don't see a net loss. If the changes make things more convenient, than it is a net gain.