It can be.
1) Usually, one player, usually the nagivator, has other make a roll, that influences how long the trip takes. Great rolls shorten time, while bad rolls lengthen it. (Sulu, Tchekov)
2) Another player is responsible for sensors, trying to detect anomalies, enemy ships, etc, with deep space scans, before it's too late. (Spok, Uhura)
3) Long trip are a good time to repair some internal systems. You can have the engineer do a challenging multiple roll repair test. (Scotty)
But if the trip takes two weeks, being on edge all the time wouldn't be fun. IF D&D PCs hire a ship to cross the ocean, there will be some encounters but 80% it will be wait time and relaxation until they approach the coast.