"Tweaking the genome" might be more about eliminating inherited genetic diseases, rather than enhancements. In TOS (and DS9) it was stated that enhancements were banned, but genetic medicine wouldn't necessarily be also banned.
It is weird to be talking about that on the ship. I mean, if she had a genetic disease or needed to be "tuned down" due to enhancements, wouldn't that have happened before she gets a notable position on a starship?