Yup, I've played it. Just one session with a visiting friend two or three years ago, so I don't have too much to say.
The system's a little rough, but quite playable. There are a few different ways given to resolve tasks (cards, multiple dice methods, etc.) and the game is set up so that each player can pick his favorite to use and everything stays balanced, which is way interesting.
Like I said, though, the system's a bit rough around the edges. There are a few holes here and there and it's sometimes a bit muddled. Overall, the quality of the actual rules and writing is along the lines of the 1st edition of Vampire: the Masquerade. There's a lot of flavor, but you're screwed if you're looking for anything in a hurry.
If nothing else, the books are filled with great ideas to mine.
The "Book of the Unliving" features multiple vampires. It's also got ghouls, which are a bit like a cross between D&D liches and WoD mummies. There are different types, but they all must feed on flesh and are themselves rotting to some degree. Some are indistiguishible from a living person, but must eat well putrified flesh for sustinence; while others look like zombies, but can pretty much eat a steak. I believe that there are also ghosts and a few other types of undead, all available as PCs.
The "Book of the Righteous" (IIRC, maybe "Book of the Divine") is filled with all sorts of stuff you'd expect to find in "Deities and Demigods". You can play a Questor which is like a Knight of the Grail, someone who has been granted immortality because of a task they have undertaken. You can also play angels (or a rose by another name). There are hero-gods and even true gods (I think, I played a vampire, so didn't spend as much time in this book) on the order of Thor or Anubis that can be played as PCs.
I know my friend was pretty psyched about the "Book of the Fantastic" coming out. Mostly, he wanted to see how they did dragons. I have to admit, I'm more than a little curious, myself.
The two unifying principles in the game is that the PCs are all immortal and the PCs are always the good guys.
Most have a way they can be killed (eg. vampires), but at least one divine type is absolutely, possitively immortal. Compare that with the Questors, who are barely immortal (basically just unaging and without disease) and you'd think there would be some balance issues, but it comes together reasonably well. There is some serious potential for Monty Hauling it, but there are enough checks built in that a good GM should be able to keep things in check. Also, the game is really built around the idea of a plot or story. I mean, really, how long can the thrill of razing every last when you're playing a god?
Also, no matter how vile you think some of the archetypes are (vampires, flesh eating ghouls, angels of destruction, etc.), the PCs are the good guys. Sure, you could bastardize the game and run amok, but the backstory really points you in the right direction. The author seems to feel pretty strongly about this and even has a couple of passages to the general effect of "If you just want to be a bad guy or revel in destruction or mayhem, I disapprove of you using my game to do so. Please go find something else to play until you can grow up."