Actually, I just got the book and I'm reading through it now. For a short book, it's extremely heavy. It reads like a textbook much of the time- there's some serious stuff happening in the game. Not to mention a 100-year timeline.
I think the setting has a lot of potential provided you can get people into it. It might be easiest to start someplace isolated, like a space station or asteroid, and introduce details gradually.
As for conversions, there's probably a GURPS-D20 set somewhere, I'd start with that and then add specifics from the setting. The various "breeds" of humans, for example, could easily be done as races. Or templates, but you have to choose race at birth, so template seems more appropriate to things like AIs and the like.